Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria.
Identifieur interne : 000356 ( Main/Exploration ); précédent : 000355; suivant : 000357Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria.
Auteurs : Charlotte Veyrat-Durebex [France] ; Christelle Debeissat [France] ; Hélène Blasco [France] ; Franck Patin [France] ; Hélène Henique [France] ; Patrick Emond [France] ; Catherine Antar [France] ; Valérie Gissot [France] ; Olivier Herault [France] ; François Maillot [France]Source :
- JIMD reports [ 2192-8304 ] ; 2017.
Abstract
BACKGROUND
Several studies have highlighted disturbance of redox homeostasis in patients with phenylketonuria (PKU) which may be associated with neurological disorders observed in patients, especially during adulthood when phenylalanine restrictive diets are not maintained. The aim of this study was to assess the antioxidant profile in a cohort of PKU patients in comparison to the controls and to evaluate its relation to biochemical parameters especially phenylalaninemia.
METHODS
We measured RNA expression of 22 antioxidant genes and reactive oxygen species (ROS) levels in white blood cells of 10 PKU patients and 10 age- and gender-matched controls. We also assessed plasma amino acids, vitamins, oligo-elements, and urinary organic acids concentrations. Then we evaluated the relationship between redox status and biochemical parameters.
RESULTS
In addition to expected biochemical disturbances, we highlighted a significant global decrease of antioxidant genes expression in PKU patients in comparison to the controls. This global decrease of antioxidant genes expression, including various isoforms of peroxiredoxins, glutaredoxins, glutathione peroxidases, and superoxide dismutases, was significantly correlated to hyperphenylalaninemia.
CONCLUSION
This study is the first to evaluate the expression of 22 antioxidant genes in white blood cells regarding biochemical parameters in PKU. These findings highlight the association of hyperphenylalaninemia with antioxidant genes expression. New experiments to specify the role of oxidative stress in PKU pathogenesis may be useful in suggesting new recommendations in PKU management and new therapeutic trials based on antioxidant defenses.
DOI: 10.1007/8904_2017_16
PubMed: 28293905
PubMed Central: PMC5740050
Affiliations:
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de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Patin, Franck" sort="Patin, Franck" uniqKey="Patin F" first="Franck" last="Patin">Franck Patin</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Henique, Helene" sort="Henique, Helene" uniqKey="Henique H" first="Hélène" last="Henique">Hélène Henique</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne, CHRU de 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Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Antar, Catherine" sort="Antar, Catherine" uniqKey="Antar C" first="Catherine" last="Antar">Catherine Antar</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Gissot, Valerie" sort="Gissot, Valerie" uniqKey="Gissot V" first="Valérie" last="Gissot">Valérie Gissot</name><affiliation wicri:level="3"><nlm:affiliation>INSERM CIC 1415, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM CIC 1415, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Herault, Olivier" sort="Herault, Olivier" uniqKey="Herault O" first="Olivier" last="Herault">Olivier Herault</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie biologique, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie biologique, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Maillot, Francois" sort="Maillot, Francois" uniqKey="Maillot F" first="François" last="Maillot">François Maillot</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U1069, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1069, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28293905</idno><idno type="pmid">28293905</idno><idno type="doi">10.1007/8904_2017_16</idno><idno type="pmc">PMC5740050</idno><idno type="wicri:Area/Main/Corpus">000362</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000362</idno><idno type="wicri:Area/Main/Curation">000362</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000362</idno><idno type="wicri:Area/Main/Exploration">000362</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria.</title><author><name sortKey="Veyrat Durebex, Charlotte" sort="Veyrat Durebex, Charlotte" uniqKey="Veyrat Durebex C" first="Charlotte" last="Veyrat-Durebex">Charlotte Veyrat-Durebex</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France. charlotte.veyrat@live.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France. charlotte.veyrat@live.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Debeissat, Christelle" sort="Debeissat, Christelle" uniqKey="Debeissat C" first="Christelle" last="Debeissat">Christelle Debeissat</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie biologique, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie biologique, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Blasco, Helene" sort="Blasco, Helene" uniqKey="Blasco H" first="Hélène" last="Blasco">Hélène Blasco</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Patin, Franck" sort="Patin, Franck" uniqKey="Patin F" first="Franck" last="Patin">Franck Patin</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Henique, Helene" sort="Henique, Helene" uniqKey="Henique H" first="Hélène" last="Henique">Hélène Henique</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U1069, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1069, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Emond, Patrick" sort="Emond, Patrick" uniqKey="Emond P" first="Patrick" last="Emond">Patrick Emond</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Antar, Catherine" sort="Antar, Catherine" uniqKey="Antar C" first="Catherine" last="Antar">Catherine Antar</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U930, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Gissot, Valerie" sort="Gissot, Valerie" uniqKey="Gissot V" first="Valérie" last="Gissot">Valérie Gissot</name><affiliation wicri:level="3"><nlm:affiliation>INSERM CIC 1415, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM CIC 1415, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Herault, Olivier" sort="Herault, Olivier" uniqKey="Herault O" first="Olivier" last="Herault">Olivier Herault</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie biologique, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie biologique, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Maillot, Francois" sort="Maillot, Francois" uniqKey="Maillot F" first="François" last="Maillot">François Maillot</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne, CHRU de Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne, CHRU de Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM U1069, Université François Rabelais Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1069, Université François Rabelais Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author></analytic><series><title level="j">JIMD reports</title><idno type="ISSN">2192-8304</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Several studies have highlighted disturbance of redox homeostasis in patients with phenylketonuria (PKU) which may be associated with neurological disorders observed in patients, especially during adulthood when phenylalanine restrictive diets are not maintained. The aim of this study was to assess the antioxidant profile in a cohort of PKU patients in comparison to the controls and to evaluate its relation to biochemical parameters especially phenylalaninemia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We measured RNA expression of 22 antioxidant genes and reactive oxygen species (ROS) levels in white blood cells of 10 PKU patients and 10 age- and gender-matched controls. We also assessed plasma amino acids, vitamins, oligo-elements, and urinary organic acids concentrations. Then we evaluated the relationship between redox status and biochemical parameters.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In addition to expected biochemical disturbances, we highlighted a significant global decrease of antioxidant genes expression in PKU patients in comparison to the controls. This global decrease of antioxidant genes expression, including various isoforms of peroxiredoxins, glutaredoxins, glutathione peroxidases, and superoxide dismutases, was significantly correlated to hyperphenylalaninemia.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>This study is the first to evaluate the expression of 22 antioxidant genes in white blood cells regarding biochemical parameters in PKU. These findings highlight the association of hyperphenylalaninemia with antioxidant genes expression. New experiments to specify the role of oxidative stress in PKU pathogenesis may be useful in suggesting new recommendations in PKU management and new therapeutic trials based on antioxidant defenses.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28293905</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2192-8304</ISSN><JournalIssue CitedMedium="Print"><Volume>37</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>JIMD reports</Title><ISOAbbreviation>JIMD Rep</ISOAbbreviation></Journal><ArticleTitle>Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria.</ArticleTitle><Pagination><MedlinePgn>73-83</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/8904_2017_16</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several studies have highlighted disturbance of redox homeostasis in patients with phenylketonuria (PKU) which may be associated with neurological disorders observed in patients, especially during adulthood when phenylalanine restrictive diets are not maintained. The aim of this study was to assess the antioxidant profile in a cohort of PKU patients in comparison to the controls and to evaluate its relation to biochemical parameters especially phenylalaninemia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We measured RNA expression of 22 antioxidant genes and reactive oxygen species (ROS) levels in white blood cells of 10 PKU patients and 10 age- and gender-matched controls. We also assessed plasma amino acids, vitamins, oligo-elements, and urinary organic acids concentrations. Then we evaluated the relationship between redox status and biochemical parameters.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In addition to expected biochemical disturbances, we highlighted a significant global decrease of antioxidant genes expression in PKU patients in comparison to the controls. This global decrease of antioxidant genes expression, including various isoforms of peroxiredoxins, glutaredoxins, glutathione peroxidases, and superoxide dismutases, was significantly correlated to hyperphenylalaninemia.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study is the first to evaluate the expression of 22 antioxidant genes in white blood cells regarding biochemical parameters in PKU. These findings highlight the association of hyperphenylalaninemia with antioxidant genes expression. New experiments to specify the role of oxidative stress in PKU pathogenesis may be useful in suggesting new recommendations in PKU management and new therapeutic trials based on antioxidant defenses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Veyrat-Durebex</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France. charlotte.veyrat@live.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U930, Université François Rabelais Tours, Tours, France. charlotte.veyrat@live.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debeissat</LastName><ForeName>Christelle</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service d'hématologie biologique, CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blasco</LastName><ForeName>Hélène</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patin</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henique</LastName><ForeName>Hélène</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Service de médecine interne, CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U1069, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emond</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antar</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U930, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gissot</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INSERM CIC 1415, CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herault</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>CNRS UMR 7292 - équipe LNOx, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service d'hématologie biologique, CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maillot</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service de médecine interne, CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U1069, Université François Rabelais Tours, Tours, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JIMD Rep</MedlineTA><NlmUniqueID>101568557</NlmUniqueID><ISSNLinking>2192-8304</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PKU</Keyword><Keyword MajorTopicYN="N">Phenylketonuria</Keyword><Keyword MajorTopicYN="N">RNA antioxidant profile</Keyword><Keyword MajorTopicYN="N">Redox status</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>02</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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